Gender differences in executive function and mood in Parkinson's disease patients after deep brain stimulation

Poster (RES)

Miwako Miyata1, Noriyuki Matsukawa2, Atsushi Umemura2, Fumiyasu Ishii1, Takehiko Yamanaka1, Kenji Okita2, Yuichi Oka2, Rika Tsuboi3, Kosei Ojika2

1) Nihon Fukushi University, Japan 2) Nagoya City University, Japan 3) Nagoya City University Hospital, Japan

Introduction: Recent reports demonstrated that subthalamic nucleus deep brain stimulation (STN-DBS) may not reduce cognitive function. Gender differences have also been reported in Parkinson's disease (PD) patients, including response to treatment, motor complications, and quality of life.

Aim: To assess and compare gender differences of executive function and depressive mood following STN-DBS.

Methods: We examined executive function and mood in 20 males and 27 females who underwent STN-DBS. Patients were evaluated 1 month before, and 1 and 12 months after surgery.

Results: The overall executive functions in the females were temporarily exacerbated and tended to recover to baseline by 12 months after STN-DBS, while only DST-B in males revealed temporary deterioration. The depressive mood in the males was also temporarily in remission 1 month after STN-DBS.

Conclusion: Our results suggest that there is a temporary gender difference after STN-DBS for executive function and depressive mood.

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